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Abstract Objective To explore the relationship between homocysteine (Hcy) level and coronary heart disease (CHD)in patients with essential hypertension. Methods A total of 200 inpatients with essential hypertension were divided into no CHD group(n=95) and CHD group(n=105) based on the results of coronary angiography.Serum Hcy was measured and compared between the two groups. The logistic regression was analyzed to determine the correlation between serum Hcy and CHD. Results Serum Hcy was significantly higher in CHD group than no CHD group[(20.2±7.4)μmol/L vs. (14.9±5.4)μmol/L](P<0.01).The percentage of CHD was 67.6% in patients with Hcy>15μmol/L and 32.4% in patients with Hcy <15μmol/L. There was significant difference between them (P<0.05). The logistic regression analysis showed Hcy was an independent predictor of CHD in essential hypertension patients [OR=1.503, 95%CI (1.280,1.739), P<0.05]. Conclusion The risk of CHD increases in hypertensive patients with Hcy increased.
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