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Abstract Objective To explore the effects of ranolazine on left ventricular function of rat during the early period after acute myocardial infarction and its mechanisms. Methods 60 SD rats were randomly divided into sham surgery group, control group, low dosage group (ranolazine, 0.05mg/kg), middle dosage group (0.5mg/kg), and high dosage group (5mg/kg). LVSP, LVEDP, dp/dtmax were measured by multi- channel biology function laboratory system, SOD activity and MDA concentration were measured by ELISA, and intracel ular calcium ion concentration was measured by colorimetric method one hour after establish of acute myocardial infarction model. Results LVEDP, ±dp/dtmax, MDA and intracel ular calcium ion concentration decreased, LVSP and SOD activity increased in ranolazine treated groups compared to control group (al P<0.05). Conclusion Ranolazine can protect left ventricular function of rat during early phase of acute myocardial infarction. This may be due to ranolazine increasing SOD activity and reducing concentrations of MDA and intracel ular calcium ion.
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