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Abstract Objective To establish an animal model of ST- segment depression induced by coronary artery stenosis and investigate its pathophysiological changes. Methods An animal model of ST- segment depression was established in 16 dogs by quantitatively constricting left circumflex coronary artery (LCCA) with a micrometer constrictor. The coronary blood flow(CBF) and blood pressure of LCCA, left ventricular peak systolic pressure(LVPSP), maximum rate of left ventricular pressure increase (dp/dt max), left ventricular end diastolic pressure(LVEDP), myocardial oxygen consumption and lactate were measured. Results ST- segment depression developed as the degree of coronary stenosis reached to 87%(cross- sectional area) with CBF reduced from(36±6)ml/min to(20±7)ml/min, distal LCCA pressure decreased from(90±14) mmHg to(55±8)mmHg, LVPSP reduced from (114±20)mmHg to(106±18)mmHg and dp/dt max decreased from(2 450± 760)mmHg/s to(2 210±700)mmHg/s), lactate increased from(26.4±6.9)%to(43.5±14)%, myocardial oxygen consumption reduced from(2.22±0.64)ml/(100g·min) to(1.37±0.83)ml/(100g·min). The differences between the parameters before and after coronary narrowed were significant (al P<0.05 or 0.01). Conclusion It is needed for establishing an acute myocardial ischemic animal model with ST segment depression to reduce 87%cross- sectional area of coronary artery.
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