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Abstract Objective To study the effects of perioperetive high- dose atorvastatin on myocardial perfusion during percutaneous coronary intervention (PCI) and recent prognosis in patients with non ST- segment elevation myocardial infarction (NSTEMI). Methods 81 patients with NSTEMI were randomized divided into experimental group (n=41) and control group (n=40).The experimental group was treated with atorvastatin 80mg once and 40mg per day for a week, then 20mg per day. The control group was treated with atorvastatin 20mg per day. TIMI blood flow grade and corrected TIMI frame count were documented during PCI. Main adverse cardiovascular events during fol ow- up of 30 days were analyzed. Results Corrected TIMI frame count was significantly lower in experimental group than in control group (P<0.05). TIMI blood flow grade and adverse cardiovascular events were not significantly different between two groups(P>0.05). Conclusion Perioperetive high- dose atorvastatin treatment can improve coronary flow during PCI in patients with NSTEMI.
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