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Abstract Objective To investigate the value of ischemia modified albumin (IMA)in early diagnosis of acute coro-nary syndrome (ACS). Methods 66 patients with unstable angina (UA), 51 patients with ST- elevation myocardial in-farction (STEMI)and 35 patients with non- ST- elevation myocardial infarction (NSTEMI)were eligible for this study. Ac-cording to the time from heart attack to blood sampling, patients were divided into 2h group (n=63), 2~4h group(n=48) and 4h group(n=41). Serum IMA, cardiac troponin I(cTnI), myoglobin(Myb)and creatine kinase isoenzyme(CK- MB) were measured and 18- lead surface ECGs were recorded in the three groups and compared to those in control group with 40 patients referred to hospital due to pectoralgia or epigastric pain. Results IMA level was significantly higher in ACS patients than control group (t=10.378, P<0. 01), and in STEMI than in UA (t=4.103,P<0.01)and NSTEMI patients (t=3.342,P<0.01). IMA was significantly lower in 4h group than 2h group (t=5.387,P<0. 01)and 2~4h group(t=5.214, P<0. 01). The positive rate of IMA+ECG was 100%in 2h,2~4h ,4h groups, which was not significant difference from IMA or ECG alone (χ2=0.204,P>0.05;χ2=0.000,P>0.05). In the diagnosis of ACS, the positive rate, positive predictive value and negative predictive value of IMA were 94.1%, 100% and 100%, respectively, and those of IMA + ECG were 96.1%, 100%and 100%, respectively. Conclusion Serum IMA increases early in ACS, which is more significant in STEMI than UA and NSTEMI patients. The positive rate of IMA is higher than ECG and traditional cardiac biomarkers.
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