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Abstract Objective To investigate the effect of dexrazoxane pre- treatment on reducing electrocardiographic events induced by antharcycline treatment of breast cancer. Methods Seventy- two patients with breast cancer were treated with or without dexrazoxane randomly before chemotherapy with anthracycline. The dexrazoxane was infused intravenously 30 minutes before epirubicin, at a dosage of 10- fold of epirubicin. Electrocardiogram was recorded at the end of chemotherapy and compared between two groups. Results One patient in group without dexrazoxane withdrew from the study for heart failure. The incidence of electrocardiographic events was significantly lower in patients pre- treated with than in patients not pre- treated with dexrazoxane (χ2=16.17, P<0.05). Conclusion Dexrazoxane pre- treatment may reduce electrocardiographic events caused by chemotherapy with antharcycline in patients with breast cancer.
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