Abstract Objective To assess the association of global left ventricular systolic function evaluated by real- time three dimensional speckle tracking imaging (RT3D- STI) with coronary artery stenosis. Methods Sixty- six patients with coronary artery stenosis determined by coronary arteriography (CAG) and no regional ventricular wal motion abnormalities on 2D echocardiography were enrol ed. Of them, 33 cases had coronary artery stenosis<70%(group A) and 33 cases had at least one coronary artery stenosis≥70%(group B). RT3D- STI was performed in al patients as wel as in 30 healthy people without coronary artery stenosis. Left ventricular end- systolic volume, end- diastolic volume, ejection fraction, global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS) and global radial strain (GRS) were measured and compared between different groups. The area under the receiver operating characteristic curve (ROC) of critical coronary stenosis was calculated. Results GLS、GCS、GRS and GAS were significantly lower in group B than in group A and controal group(al P<0.05). GLS and GAS were significantly lower in group A than in control group( al P<0.05). ROC curve showed that GAS had higher sensitivity and specificity than other parameters in detecting critical coronary artery stenosis. GAS was highly correlated with left ventricular ejection fraction. Conclusion RT3D- STI can detect abnormal left ventricular contraction which are difficult to been found by 2D echocardiography. GAS is correlation with coronary artery stenosis.
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