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Abstract Objective To compare transradial and transfemoral artery approach for percutaneous coronary intervention (PCI) of acute myocardial infarction (AMI). Methods 308 patients underwent primary PCI for AMI from Jan 2006 to Nov 2011 were analyzed retrospectively. They were divided into transradial (TR group, n=186) and transfemoral groups (TF group, n=122) based on primary access site. The success rate, operation time, complications of primary PCI and main adverse cardiovascular events (MACE) were compared between two groups. Results The success rate (91.9% vs 92.6%), operation time (55.3±19.3 vs 56.1±20.4min)and MACE during hospitalization were not significantly difference between TR and TF groups (P >0.05). The crossover rate of vascular access was 9.7% in TR group, significantly higher than 2.5%in TF group(P<0.05). The operation- related complications(10.8%vs 20.5%), bed- rest time (5.3±2.5 vs 22.1±5.0h), and MACE within 1 and 2 years after procedure(6.5%,13.9%vs 13.4%,23.0%) were significantly lower in TR group than TF group (al P<0.05). Conclusion Transradial approach may reduce vascular access- related complications and bed- rest time but with a higher crossover rate of vascular access during primary PCI of AMI.
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