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Abstract Objective To explore the value of serum growth differentiation factor- 15 (GDF- 15) in the diagnosis and prognostic prediction of heart failure (HF) with preserved ejection fraction (HF- PEF). Methods 62 patients with HFPEF, 68 patients with HF and a reduced ejection fraction (HF- REF) and 40 healthy subjects were enrolled. Serum GDF- 15 and NT- proBNP concentration, left ventricular ejection fraction, left ventricular end diastolic dimension were measured. HF- PEF and HF- REF patients received conventional treatment and were followed up for 2 years. Results Serum GDF- 15 in HF- PEF patients was significantly higher than that in healthy subjects (P<0.01) and lower than that in HF- REF patients (P<0.01). The area under the receiver operating characteristic curve (AUC) for diagnosis of HFPEF was 0.814 for GDF- 15, significantly higher than 0.764 for NT- proBNP(P<0.05). AUC of GDF- 15 combined with NT- proBNP was 0.829, higher than either one alone (P<0.05). AUC for prediction of HF- related adverse events was 0.825 for GDF- 15 and 0.805 for NT- proBNP, which was 0.832 for GDF- 15 combined NT- proBNP and significantly higher than either of them (P<0.05). Conclusion Serum GDF- 15 is helpful in the diagnosis and prognostic prediction of HF- PEF, especial y when combined with NT- proBNP.
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