|
Abstract Objective To observe the changes of platelet CD62P and CD63 concentrations after abrupt or gradual withdrawal of clopidogrel in patients underwent PCIl. Methods 64 patients being treated with dual antiplatelet drugs (aspirin and clopidogrel) more than 12 months after coronary drug- eluting stents implantation were enrol ed. Clopidogrel was stopped abruptly in 32 patients(control group) or taken every other day in 4 weeks and then stopped in other 32 patients (experimental group) . CD62P and CD63 were measured immediate before the study, and at 1,2,4 and 12 weeks later, respectively. They were fol owed up for 6 months. Results Compared with control group, CD62P and CD63 were significantly higher in experimental group at week 1 (17.73 ±1.87% vs 12.54 ±1.61%, 16.85 ±1.53% vs 12.66 ±1.32%, respectively, both P<0.01 ) and week 2 (16.24±2.18%vs 12.76±1.33%, 15.96±1.75%vs 12.87±1.29%, both P<0.05). CD62P and CD63 were significantly higher at week 12 than baseline in both groups, with no significant difference between groups. No main adverse cardiovascular event occurred during 6- month fol ow- up. Conclusion Rebound platelet reactivity is evident after discontinuation of clopidogrel. Reducing the dose of clopidogrel fol owed by withdrawal may alleviate this rebound phenomenon.
|
|
|
|
|
|
