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Abstract Objective To investigate the effect and safety of warfarin anticoagulation in ultra- low intensity in octogenarians with nonvalvular atrial fibril ation (NVAF). Methods 37 NVAF patients aged ≥80 years old and with HAS- BLED score≥3 were treated with warfarin. International normalized ratio was control ed to a range of 1.4 to 1.9 in ultra- low intensity group (ULI group) and 2.0 to 2.5 in low intensity group (LI group). Al patients were fol owed up for 12 months.The ischemic stroke and bleeding events were assessed. Results CHA2DS2- VASc and HAS- BLED scores were similar between ULI and LI group[(3.50±0.89)vs.(3.40±0.97), (4.70±0.98)vs.(5.10±0.93),respectively] . The incidence of ischemic stroke was similar in ULI and LI group (5.0% vs. 5.8%, P >0.05), while the severe and mild bleeding was significantly more frequent in LI group (5.9%and 23.6% )than ULI group ( 0 and 10%)(P<0.05). Conclusion Warfarin anticoagulation in ultra- low intensity has similar effect as that in low intensity on prevention of stroke in octogenarians with NVAF, but with lower bleeding risk.
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