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Abstract Objective To evaluate the value of multidetector coronary computed tomography angiography(CTA) combined with treadmil exercise test (TET) in predicting prognosis of coronary artery lesion. Methods The data of 595 patients with suspected coronary artery disease underwent both coronary CTA and TET were analyzed retrospectively. Coronary CTA results were classified to normal, mild stenosis(<40%of luminal stenosis), moderate stenosis(40%to 69%), and severe stenosis (>70%). TET results were categorized as positive and negative. Duke TET score was calculated. Major adverse cardiac events (MACE) during fol ow- up 1.52 to 3.31 years were recorded. Results 39 MACE were observed and 3- year cumulative event rate was 2.74%. Coronary CTA improved risk stratification. TET combined with coronary CTA was not superior to coronary CTA alone in risk categorization. In patients with moderate and severe coronary stenosis on coronary CTA, positive TET predicted MACE with HR 2.6 (95%CI:1.31~5.22, P<0.01) and HR 2.35( 95%CI:1.22~4.83, P<0.05), respectively. Conclusion Positive TET is predictive for prognosis in patients with moderate to severe stenosis on coronary CTA.
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