|
Abstract Objective To investigate the effect of Valsartan combined with Amiodarone on cardioversion of persistant atrial fibrillation (AF) and maintenance of sinus rhythm after cardioversion. Methods 96 patients with permanent AF were randomly divided into control group(n=47) and Valsartan group (n=49). The conversion rate of AF at one year and reoccur-rence of AF at 3 and 12 months after cardioversion were investigated. Left atrial dimension and left ventricular ejection frac-tion (LVEF) were measured at the moment of cardioversion and 12 months after cardioversion. Results The rate of AF cardioversion was not significant difference between two groups (87.8%vs 85.1%, P>0.05). The recurrence rate was sig-nificantly lower in Valsartan group than control group at 3 months (14.0% vs 32.5%, P<0.05) and 12 months (23.2% vs 54.5%, P<0.01). Left atrium significantly decreased (44.3 ±0.65 mm vs 46.9 ±0.54 mm, P<0.05) and LVEF increased (56.8±8.64%vs 52.3±9.08%, P<0.05) in Valsartan group at 12 months. Conclusion Valsartan with Amiodarone is su-perior to Amiodarone alone in maintaining sinus rhythm and improving heart function in the patients with permanent AF.
|
|
|
|
|
|
