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Abstract Objective To analyze the correlation of serum homocysteine(Hcy), uric acid and retinol- binding protein4 (RBP4) with coronary heart disease (CHD). Methods 503 cases with CHD diagnosed by coronary angiography were classified into MI group (n=84, including acute and subacute myocardial infarction), unstable angina (UA) group (n=312) and stable angina (SA) group (n=107) based on their clinical characteristics. 100 cases without CHD were included as control group. Serum Hcy, uric acid and RBP4 were measured and their correlations were determined by Pearson test. The risk factors for CHD were analyzed by multivariate logistic regression. Results The level of Hcy and uric acid, but not RBP4, were significantly higher in MI,UA and SA groups than those in control group (P<0.05), ranked in the order of MI group>UA group>SA group>control group. Multivariate logistic regression analysis showed that Hcy was a risk factor for CHD. Hcy, uric acid and RBP4 were correlated to smoking, TG and ApoA1. Uric acid was correlated to Hcy and RBP4. Conclusion Hcy and uric acid are obviously associated with CHD. Their serum levels are consistent with the severity of CHD. Hcy is a risk factor for CHD.
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