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Abstract Objective To evaluate the efficacy of smal doses of recombinant hBNP in the treatment of acute decom-pensated heart failure (HF). Methods 63 patients hospitalized for acute decompensated HF were randomly treated with regular dose of rhBNP (n=32) or smal dose of rhBNP (n=31). Clinical symptoms and signs were evaluated, left ventricular end- diastolic diameter (LVEDd) and left ventricular ejection fraction (LVEF) were measured before and after treatment. Results Clinical symptoms and signs were improved significantly in both groups. The overal efficacy was 93.8%in reg-ular dose group and 90.3%in smal dose group. There was no significant difference between them (P>0. 05). LVEF, but not LVEDd, was significantly improved after treatment (P<0.01). LVEDd and LVEF were not significantly different between two groups (P>0. 05). Conclusion Smal dose of rhBNP may improve heart function as wel as regular dose of rhBNP in acute decompensated HF.
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