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Abstract Objective To discuss the correlation of neutrophil to lymphocyte ratio(NLR) and red blood cel distribution width (RDW) with coronary artery lesion severity in stable coronary artery disease. Methods 131 cases underwent coronary angiography. Of them, 94 cases were diagnosed as coronary artery disease CAD(CAD group) for artery stenosis≥50%in at least one of left main artery, left anterior descending artery, left circumflex artery, right coronary artery or their main branch, 37 cases had normal coronary artery (control group). According to SYNTAX score, CAD group were divided into high risk subgroup (SYNTAX score≥33, n=43), middle risk subgroup (22≤SYNTAX score<33, n=22) and low risk subgroup (SYNTAX score<22, n=29). RDW, neutrophil and lymphocyte of venous blood were measured and NLR was calculated. They were compared between different groups and subgroups. The correlations of NLR and RDW with the severity of coronary artery lesion were determined. Results NLR and RDW levels were significantly higher in CAD group[(2.90±2.28)%, (13.54±0.92)%, respectively] than in control group [(1.69±0.64)%, (12.67±0.42)%](t=4.69、7.49, al P<0.01). NLR was significantly higher in high risk subgroup(3.78±2.91)%than in middle and low risk subgroups[(2.36± 1.09)%, (2.01±1.21)%,respectively] (t=2.83、3.56, al P<0.01). NLR was positively correlated with SYNTAX score(r=0.331, P<0.01). Logistic regression analysis showed that NLR was an independent predictor of high risk CAD (OR=2.070, P<0.01). Conclusion NLR and RDW increase in CAD. NLR is correlated with the severity of coronary artery lesion in stable coronary artery disease.
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