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Abstract Objective To investigate the effects of different doses of atorvastatin on renal artery atherosclerosis and renal function. Methods 75 patients with atherosclerotic renal artery stenosis (ARAS) determined by spiral computed tomography were enrol ed. They took atorvastatin 20 mg daily (group 1, n=31) or 40 mg daily(group 2, n=44). LDL- C, hs- CRP, tumor TNF- α and IL- 6 were measured before and one month after treatment. The eGFR and renal artery stenosis were calculated before and 3 years later after treatment. Results LDL- C, hs- CRP, TNF- α, IL- 6, eGFR, and the degree of ARAS were not significant difference between two groups before treatment. They decreased significantly except the eGFR increased significantly after treatment in both groups(al P<0.05). hs- CRP, TNF- αand IL- 6 were significantly lower, while the eGFR and the improvement of ARAS were significantly higher in group 2 than in group 1 (al P<0.01). The eGFR was negativly related to the percentage of ARAS after treatment (r=- 0.42, P<0.05) but not before treatment. Conclusion Atorvastatin improves renal function in dose- dependent manner. It may be related to the reduction of inflammatory and ARAS.
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