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Abstract Objective To determine the value of speckle- tracking of mitral annular displacement (TMAD) in evaluating the changes of left ventricular systolic function after paclitaxel chemotherapy. Methods Left ventricular end- diastolic dimension (LVEDd), Left ventricular end- diastolic volume (LVEDV), Left ventricular end- systolic volume (LVESV), and Left ventricular ejection fraction (LVEF) were measured with conventional echocardiography, and the maximal displacement of six points of mitral annulus (Ds) was measured by speckle- tracking echocardiography in 52 cancer patients before and after chemotherapy. Results LVEDd, LVEDV, LVESV increased significantly after than before chemotherapy (P<0.05). LVEF decreased insignificantly. The maximal displacement of six points of mitral annulus decreased accordingly after chemotherapy. The posterior- septal motion significantly decreased (P<0.05). Conclusion TMAD may be benefit to evaluating the left ventricular systolic function change in cancer patients after paclitaxel chemotherapy.
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