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Abstract Objective To analyze the characteristics of coronary lesions and influence factors in elderly patients with coronary heart disease (CAD) and obstructive sleep apnea syndrome (OSAHS). Methods A total of 64 patients with both CAD and OSAHS were divided into mild OSAHS group (n=22), moderate OSAHS group (n=24) and severe OSAHS group (n=18). 32 patients with only CAD served as control group. Syntax score was used to evaluate the severity of coronary lesions. Blood pressure, body mass index (BMI), smoking index, low density lipoprotein cholesterin (LDL- C), glucose (GLU), hsCRP, IL- 6 and TNF- α were compared between groups. Results BMI, SBP, Syntax score, hs- CRP, IL- 6, TNF- α, smoking index and LDL- C were significantly higher in patients with both CAD and OSAHS than in control group, and increased as the exacerbation of OSAHS. Multivariable regression analysis revealed that BMI, SBP, hs- CRP, IL- 6, TNF- α, smoking index and LDL- C were correlated with Syntax score. Conclusion Coronary artery lesions are severe in elderly patients with both CAD and OSAHS, and closely related to low ventilation, smoking and inflammation.
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