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Abstract Objective To investigate the changes and clinical significance of soluble ST2 protein (sST2) and interleukin- 6 in patients with chronic heart failure (HF). Methods 100 inpatients with HF (HF group) and 60 inpatients without HF (control group) were enrol ed between July 2012 and July 2015.Heart function was graded based on NYHA heart function classification. The left ventricular ejection fraction (LVEF)and fractional shortening (LVFS) were measured by two- dimensional echocardiography. sST2 and IL- 6 levels were measured by enzyme- linked immunosorbent assays at admission.Serum NT- proBNP was measured. Results Serum sST2 and IL- 6 in were significantly higher in HF group than control group. Serum levels of sST2 and IL- 6 increased significantly as the NYHA classification increased. Serum sST2 and IL- 6 level was negatively correlated with NT- ProBNP, LVFS and LVEF. Conclusion sST2 and IL- 6 levels increase in patients with HF and correlate with the severity of HF.
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