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Abstract Objective To investigate the relationship between plasma free tri odothyronine (FT3) level and short- and long- term prognosis of patients with acute heart failure (AHF). Methods A total of 716 AHF patients were enrol ed in this study. Plasma thyroid hormone, renal function, electrolytes and brain natriuretic peptide (BNP) were measured within 24h after admission. The patients were grouped according to quartile of FT3 level. The correlation between thyroid hormone level and al- cause mortality was assessed using logistic regression and Cox hazards model. Results 214 patients (34.6%) died during fol ow- up of 19 ±13 months. The al- cause mortality increased as FT3 level decreased. Multivariate Cox analysis showed FT3 was an independent predictor for both thirty- day mortality (HR=0.812, 95%CI 0.615~1.009, P<0.01) and long- term al- cause mortality (HR=0.789, 95%CI 0.664~0.937, P<0.01) .Kaplan- Meier analysis showed significant difference in mortality between 2nd to 4th quartiles and 1st quartile(P<0.01). Conclusion AHF patients with low FT3 level may have higher short- and long- term al- cause mortality.
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