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Abstract Objective To investigate the changes of electrocardiogram (ECG)in patients with primary hepatic carcinoma and its related factors. Methods The clinical data of 335 patients with primary hepatic carcinoma admitted from January 1997 to January 2014 were retrospectively reviewed. The association of ECG changes with serum γglutamyl transferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), potassium, and calcium levels were analyzed. Results Among 335 patients, 69 cases had normal ECG (20.60%)and 266 had abnormal ECG findings (79.40%). The abnormities in ECG were mainly ST- T segment change and/or U wave change, arrhythmia, prolongation of ST segment and/or Q- T interval. The abnormity rate of ECG in patients≥60 y was significantly higher than that in patients<60y (X2=11.997,P<0.05). The abnormity rate of ECG in patients with high level of serum GGT and abnormal serum electrolyte was higher than that in patients with normal GGT (X2=8.324,P<0.05)or that in patient with normal electrolyte (X2=12.074, P<0.05). The multivariate Logistic regression showed that age≥60y, elevated GGT, and serum electrolyte abnormality were independent risk factors of abnormal ECG findings. Conclusion The ECG abnormalities are related to older age, elevation of GGT and serum electrolyte abnormality.
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