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Abstract Objective To explore the association between thyroid hormone levels and the number of diseased vessels in acute coronary syndrome (ACS). Methods Serum thyroid hormones were measured by chemiluminescence immunoassay in 345 patients with ACS(105 with single- vessel disease,68 with 2 vessel disease,69 with 3- vessel disease) as wel as 103 healthy people(control group). Thyroid hormone levels were compared among groups. Results The level of free tri odothyronine (FT3) was significantly lower in each ACS subset than in control group (t=2.107、2.818、4.077, al P<0.05), even after excluding the patients with acute myocardial infarction or NYHA III to IV, respectively(t=3.625、2.297、2.060, al P<0.05; t=2.254、13.232、10.307, P<0.05).The levels of FT3 was significantly lower in 3- vessel disease group than in 2- vessel and single- vessel disease group (t=1.798、2.974 , al P<0.05). There was no significant difference of total tri odothyronine,total thyroid hormone,free thyroid hormone,and thyrotropin between control group and each ACS subset. Conclusion The change of FT3 within normal range is associated with the number of diseased vessels in ACS.
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