|
Abstract Objective To evaluate the effects of Rosuvastatin on serum IL- 6 and lipid in high- fat diet- induced obese rats. Methods Thirty male rats were divided into obese(n=20) and control(n=10)groups randomly, and fed a high- fat diet and a standard diet,respectively,for 14 weeks. Obesity was determined based on body weight increment. Serum TC、TG、HDL- C 、LDL- C and IL- 6 were measured. Obese rats were treated with Rosuvastatin. Serum lipid and IL- 6 were compared before and after treatment of Rosuvastatin. Results The levels of serum TG, TC, LDL- C and IL- 6 were significantly higher in obese group than those in the control group(P<0.01) .The level of IL- 6 was significantly correlated with TC and LDL- C levels (r=0.72、0.71, P<0.01). Rosuvastatin significantly decreased serum lipid and IL- 6 of obese rats. Conclusion Serum IL- 6 increases obviously in high- fat diet- induced obese rats. Rosuvastatin could reduce serum IL- 6 as wel as lipid.
|
|
|
|
|
|
