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Abstract Objective To evaluate the prognostic value of plasma PTX3 in patients with chronic heart failure(CHF). Methods A total of 406 consecutive patients with CHF were prospectively enrol ed in this study and fol owed up for 2 years. Plasma PTX3 level was measured in the second morning after hospitalization. Al-caused death, re-hospitalization for heart failure, acute myocardial infarction, stoke and peripheral arterial embolism were documented. The relationship between plasma PTX3 and cardiovascular events (CVE) were analyzed. Results 376 patients had been fol owed up for 2 years, of them, 171 patients experienced CVE. Plasma PTX3 level was significantly higher in patients with than without CVE (3.911±0.83ng/ml vs 3.088±0.99ng/ml, P<0.01) and positively related to the severity of heart failure (P<0.01). CVE were more frequency in patients with increased PTX3 (≥median value 3.438ng/ml) than those without(63.5%vs 27.3%, P<0.01). Kaplan-Meier analysis revealed that patients with increased PTX3(≥3.438ng /ml) had a significantly lower survival rate without CVE (P<0.01). Multi-factor analysis showed that increased PTX3 was an independent risk factor for CVE in patients with CHF (RR=4.224, P<0.01;95%CI 1.130~15.783). Conclusion CHF patients with increased PTX3 have a higher risk of developing CVE. Increased PTX3 may be an independent predictor for prognosis of patients with CHF.
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