|
Abstract Objective To evaluate clinical significance of oral glucose tolerance test (OGTT) and lifestyle intervention in young patients with coronary artery disease (CAD). Methods 270 patients≤45 years of age with CAD received OGTT. They were diagnosed as having diabetic mellitus (DM), impaired glucose tolerance (IGT) or normal blood glucose (BG). The severity of CAD was analyzed. According to patient's intention and ability to execute lifestyle intervention, those with DM and IGT were divided into interventional group and control group. OGTT, BG, HbA1c, body mass index were compared before and after 3 months of intervention. Results Multiple-vessel disease was found in 81.4%patients with DM, 75.6% with IGT and 37.9% with normal BG. The extent of CAD was similar between patients with DM and IGT, but more significant than that of patients with normal BG (P<0.01). There were significant differences of fast BG, BG 2 hours after meal,HbA1c and body mass index before and after lifestyle intervention (al P<0.01). Conclusion OGTT is useful for detecting prediabetes. Patients with DM or IGT had extensive and serious coronary artery disease. Lifestyle intervention can obviously reduce BG and delay development of type 2 diabetes.
|
|
|
|
|
|
