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Abstract Objective To investigate the effects of Angiotensin (Ang)Ⅱon the expression of catalase of rat vessels. Methods 18 rats were randomly divided into Ang II group (n=6)infused with Ang II by micro- pump and saline group (n=6) infused with saline for 14 days, and control group(n=6). Systolic pressure of tail artery was measured at 0,3,7 and 14 day. The rats were sacrificed for observing vessel morphological changes at 14th day. Catalase and oxidative stress product- 4HNE were determined by immunohistochemistry. Results Systolic blood pressure of tail artery as wel as the thickness of carotid artery media increased significantly, Catalase was significantly lower while oxidative stress product- 4HNE was higher in Ang II group compared to control group (al P<0.01). Conclusion AngⅡ may promote oxidative stress through inhibiting catalase expression of rat vessels.
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