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Abstract Objective To investigate the correlation of glycosylated hemoglobin with the number of coronary vessels diseased and cardiac function in patients with coronary artery disease (CAD). Methods 253 patients with CAG determined by coronary angiography were divided into normal group (n=75, HbA1c≤5.6%), borderline group (n=85, HbA1c 5.7%~6.4%) and abnormal group (HbA1c≥6.5%, n=89) based on HbA1c. Of them, 95 cases had single- vessel disease, 103 had two- vessel disease and 55 had multi- vessel disease. The relation of HbAlc with the number of coronary vessels diseased and cardiac function was analyzed. Results HbAlc was positively correlated with the number of coronary vessels diseased (r=0.75, P<0.01), and highest in patients with three- vessel disease and lowest in those with single- vessel disease. Left ventricular end- diastolic diameter(LVEDd) and B- type natriuretic peptide(BNP) increased and left ventricular ejection function (LVEF) decreased from normal group to borderline group to abnormal group with a significant difference between groups (al P<0.01). HbAlc was positively correlated with LVEDd and NBP (r=0.73、0.62, P<0.05) and negatively correlated with LVEF (r=- 0.58, P<0.05). Conclusion Patients with HbAlc increased have more coronary vessels diseased, a larger left ventricle and impaired heart function.
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