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Abstract Objective To evaluate the effects of Shenmai injection with primary percutaneous coronary intervention (PCI) on aldosterone, B- type natriuretic peptide (BNP)and left ventricular function in patients with acute anterior myocardial infarction (AAMI). Methods 38 patients underwent primary PCI for AAMI were randomized divided into Shenmai group(n=19) and control group(n=19). Al patients received regular therapy. Patients in Shenmai group received Shenmai injection 50mg/d for 15 days on the basis of regular therapy. The serum ALD and BNP were measured before, 2 weeks and 24 weeks after PCI. Echocardiography was performed at 2 weeks and 24 weeks after PCI. Results The levels of ALD and BNP were not significantly different between Shenmai and control groups at 2 weeks, but significantly lower in Shenmai group than control group at 24 weeks. Wal motion index was significantly lower, and left ventricular ejection fraction was significantly higher in Shenmai group than control group at 24 weeks (al P<0.01). Conclusion Shenmai injection may improve left ventricular function in patients with AAMI after primary PCI.
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