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Abstract Objective To evaluate the efficacy and safety of ibutilide in cardioversion of atrial fibril ation (Af) and artial flutter (AF) after amiodarone cardioversion failed. Methods 63 patients with Af or AF were included in the study. 52 pa-tients were first treated with amiodarone and then ibutilide was administered to those unsuccessful y treated with amio-darone (group A). 11 patients were only treated with ibutilide(group B). Results 45 cases (86.5%) were converted to si-nus rhythm in group A. Of them, 25 cases were treated with amiodarone and 20 cases with amiodarone plus ibutilide. Car-dioversion was successful in 7 cases (63.6%) in group B. The success rate was significant difference between group A and B (P<0.01). 57.1% Af was converted to sinus rhythm in group B, which was significantly lower than that treated with amiodarone plus ibutilide(84.8%, P<0.01), but higher than that treated with amiodarone(48.1%, P<0.05). One patient had a sinus arrest of 7.4s during ibutilide therapy in group A. Conclusion Ibutilide may improve efficacy of amiodarone in cardioversion of Af and AF. It is necessary to pay attention to sinus node function in patients treated with both amiodarone and ibutilide.
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