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Abstract Objective To investigate the changes of tumor necrosis factor alpha (TNF- α) and interleukin- 6 (IL- 6) in hypertensive patients with prediabetes. Methods 133 cases were enrol ed and divided into control group(39 cases), hypertension group(34 cases) and hypertension with prediabetes group(60 cases). Fasting blood glucose, postprandial glucose, lipid level, HbA1c, renal and hepatic function, and hypersensitive CRP were examined routinely. Serum TNF- a and IL- 6 were measured by ELISA. Results The levels of TNF- a and IL- 6 in hypertension with prediabetes group [ (114.68 ±15.39)pg/ml, 24.58 ±2.89] pg/ml, respectively] and hypertension group [(97.30 ±13.78)pg/ml, (24.02 ±2.54) pg/ml] were significantly higher than in control group [(51.90±7.83)pg/ml, (12.67±2.22)pg/ml ](al P<0.01). TNF- a was significantly higher in hypertension with prediabetes group than in hypertenison group (P<0.01). The correlation analysis showed that the correlation coefficients between TNF- a and SBP, DBP, HbA1c were 0.769, 0.673, 0.622, respectively (P<0.01), and those between IL- 6 and SBP, DBP, HbA1c were 0.798, 0.695, 0.525, respectively (al P<0.01). The multiple regression analysis showed that blood pressure, FBG, HbA1c were the independent risk factors of TNF- a and IL- 6 (al P<0.01). Conclusion Serum TNF- a and IL- 6 increase in both Hypertension and prediabetes, and more significantly in hypertension with prediabetes.
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