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Abstract Objective To explore associated risk factors of clopidogrel resistance in patients with coronary artery disease(CAD) after percutaneous coronary intervention(PCI). Methods 108 CAD patients underwent PCI. They were treated with oral aspirin 300 mg and clopidogrel 300 mg before and aspirin 100 mg and clopidogrel 75 mg daily after PCI. Thrombelastography was performed at the third day post PCI. The patients were divided into clopidogrel resistance group and non- clopidogrel resistance group based on adenosine diphosphate (ADP) induced platelet aggregation inhibition < or > 30%. The histories of diabetes, hypertension and smoking, serum lipid, platelet count, fast blood sugar and C- reaction protein were analyzed and compared between groups. Results Clopidogrel resistance occurred in 42 cases. There was significant difference of the history of smoking and diabetes,and platelet counts between the two groups (al P<0.05). Logistic regression analysis showed that no- smoking history(OR=4.707, 95%CI=1.796~12.316, P<0.01), history of diabetes (OR=3.625, 95%CI=1.363~9.641, P<0.05), and high platelet counts(OR=0.990, 95%CI=0.983~0.997, P<0.01) were independent risk factors of clopidogrel resistance. Conclusion The incidence of clopidogrel resistance is higher in CAD patients after PCI. No- smoking history, diabetes and high platelet counts are risk factors of clopidogrel resistance.
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