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Abstract Objective To investigate the relationship between serum ALP levels and the severity of coronary stenosis in patients with coronary heart disease (CHD). Methods Clinical data were analyzed retrospectively in 470 inpatients with CHD. Serum ALP levels>129 U/L in men and>104 U/L in women were defined as elevated. Gensini score was used to evaluate coronary artery stenosis and greater than 40 means significant coronary artery stenosis. Multivariable logistic regression analysis was performed to analyze factors related to coronary stenosis. Results 329 patients had significant coronary artery stenosis and 114 patients had non- significant coronary artery stenosis. ALP levels (105.4±60.7 vs.78.4± 38.7 U/L, P<0.01) and the percent of patients with elevated ALP levels (22.0 vs. 5.0%, P<0.01) were significantly higher in patients with significant coronary stenosis than with non- significant coronary stenosis. Regression analysis showed serum ALP elevation was an independent factor associated with coronary stenosis (OR 1.013, 95% CI 1.003~1.023, P<0.05). Conclusion The elevated ALP level maybe associated with coronary artery stenosis.
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