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Abstract Objective To investigate the association of serum uric acid and high- sensitivity C- reactive protein (hs- CRP) with thromboembolic events in patients with nonvalvular atrial fibril ation (NVAF). Methods 462 in- patients with NVAF were retrospectively analyzed and divided into embolism (n=63) and non- embolism (n=399) group based on with or without thromboembolic events. The risk factors for thromboembolism were compared between two groups. The relationship between serum uric acid and thromboembolic events was analyzed. Results Hypertension, diabetes, coronary heart disease, cardiac dysfunction, and people with age≥75 years were seen more frequently, serum uric acid, hs- CRP and fibrinogen were significantly higher, while left ventricular ejection fraction was significantly lower in embolism group than in non- embolism group(P<0.05). There was significant correlation between serum uric acid and hs- CRP(r=0.787, P<0.01). Multivariate logistic regression analysis showed that increased uric acid was an independent risk factor for thromboembolic events in patients with NVA (OR1.05, 95%CI1.02- 1.17, P<0.05). Conclusion Elevated uric acid is associated with thromboembolic events in patients with NVAF.
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