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Abstract Objective To explore the plasma cardiotrophin- 1(CT- 1) level and its correlation with the disease severity in children with heart failure (HF). Methods Plasma CT- 1 and brain natriuretic peptide (BNP) were measured, left ventricular ejection fraction(LVEF) was determined by echocardiography in 96 children with chronic HF(HF group) and 30 healthy children (control group). The correlations of plasma CT- 1 with BNP and LVEF were analyzed in HF group. Results Plasma CT- 1 and BNP were significantly higher and LVEF significantly lower in HF group than in control group (P<0.01,<0.05). In HF group, plasma CT- 1 and BNP increased and LVEF decreased significantly along with NYHA grade increasing (al P<0.01), plasma CT- 1 was positively correlated with BNP (r=0.71, P<0.01) and negatively correlated with LVEF (r=- 0.43, P<0.01). Conclusion Plasma CT- 1 increases in children with HF and may predict the severity and prognosis of the disease.
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