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Abstract Objective To investigate the relationship between heart rate turbulence and 24-hour urine protein in type 2 diabetes mellitus(DM). Methods 57 type 2 DM patients with ventricular premature beat were divided into normoatbu-minuria group (group A, n=18), microalbuminuda group (group B, n=19), albuminuria group (group C, n=20). Turbu-lence onset (TO) and turbulence slope (TS) were calculated based on 24-hour ambulatory ECG and compared among different groups. Results TO was significantly higher in group C (0.08 ± 0.67)% and group B (0.07 ±0.72)%than in group A(-1.79 ± 0.41 }%(all P < 0.01). TS were significantly lower in group C(5.09 ± 1.28) ms / R-R and group B(5.01±1.04)ms / R-R than in group A(8.39 ± 1.05)ms / R-R (all P < 0.01). Conclusion TO increases and TS decreases ob-viously and their changes are closely related to 24-hour urine protein measurements in type 2 DM patients.
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